Dr. Peeples’ main interest is respiratory syncytial virus (RSV), a major pathogen for infants and the elderly and a major target for vaccine development. His laboratory studies the viral entry process, attachment and membrane fusion, and the two proteins responsible for each functions, in primary well differentiated human airway epithelial cultures, the in vivo target cells for RSV. They have recently identified the major receptor for RSV on the cilia of the apical ciliated cells in these cultures. They are using these cultures to assess neutralizing antibodies and the live attenuated RSV vaccines that they are developing. They also produce these cultures for the Cystic Fibrosis community at OSU and Nationwide Children’s.