Research Description

The lysosome, a key player in cellular homeostasis and stress response, is crucial for maintaining cell health. Dysfunctional lysosomal responses to stress can lead to cell death and organ dysfunction. Lysosomal dynamics include the dynamic processes involved in the movement, positioning, and upkeep of lysosomes within a cell. A comprehensive grasp of lysosomal dynamics is vital for understanding how cells regulate their internal milieu and adapt to diverse cellular and environmental stimuli.

In neurodegenerative diseases like Parkinson's (PD), Alzheimer's (AD), and Amyotrophic lateral sclerosis (ALS), lysosomal dysfunction is a common factor. In the Bonet-Ponce lab, we focus on deciphering lysosomal functionality, especially its response to cellular stress. Our research combines genetic insights and cell biology to explore lysosomal proteins associated with a higher risk of neurodegenerative diseases. We investigate their roles, examining the impact of pathogenic mutations on function and the broader cellular landscape.

Understanding lysosomal dynamics is not only fundamental to cell biology but also holds promise for developing therapies targeting diseases rooted in lysosomal dysfunction.