Our research interests lie at the intersection of analytical chemistry and chemical biology, with a focus on cancer biology. Cancer is a complex disease, requiring sophisticated and systematic strategies to deliver knowledge that will lead to improved treatment options for patients. Individuals trained in a wide range of scientific topics and possessing a substantial breadth of knowledge are best positioned to tackle this challenge. In the Hummon Research Group, we develop analytical methods to evaluate both the transcriptome and the proteome in cancer cells, while exploring the deregulation in cancer-associated signal transduction pathways.
Cancer arises from insults to the genome. With genomic damage, the expression levels of genes are altered from their normal state. Changes in the genome, transcriptome and proteome have been found to be highly conserved among samples from adenomas to carcinomas to metastases. Because genetic changes are commonly repeated among cancer patients, a better understanding of which genes, transcripts, and proteins are affected could have broad health implications. Therefore, the best way to understand the molecular underpinnings of cancer is to dissect the deregulated pathways that are contributing to the cancer phenotype, identify the aberrantly expressed genes and their products, and decipher their effect on downstream targets.