Title Investigators
Accurate protein structure prediction with hydroxyl radical protein footprinting data Sarah Biehn, Steffen Lindert
Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding Justin North, Michael Poirier, Jonathan W Picking (OSBP alumni), Mridula Manohar, Alex M Mooney, Robin J Nakkula, Annick Edon, Richard Fishel, Jennifer J Ottesen
Cadaverine Is a Switch in the Lysine Degradation Pathway in Pseudomonas aeruginosa Biofilm Identified by Untargeted Metabolomics. Abigail Leggett, Rafael Brüschweiler, Da-Wei Li, Devin Sindeldecker, Amelia Staats, Nicholas Rigel, Lei Bruschweiler-Li, Paul Stoodley
Chemical footprinting and kinetic assays reveal dual functions for highly conserved eukaryotic tRNAHis guanylyltransferase residues Jane Jackman, Ashanti O Matlock (OSBP alumni), Brian A Smith (OSBP alumni)
Controlling the Direction of S-Nitrosation versus Denitrosation: Reversible Cleavage and Formation of an S-N Bond within a Dicopper Center. Alina Yerbulekova, Hannah Shafaat, Tao W, Moore CE, Zhang S
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury. Julian Aldana Aroca, Ana I Salazar-Puerta, Maria A Rincon-Benavides, Tatiana Z Cuellar-Gaviria, Gabriela Vasquez Martinez, Lilibeth Ortega-Pineda, Devleena Das, Daniel Dodd, Charles A Spencer, Binbin Deng, David W McComb, Joshua A Englert, Samir Ghadiali, Diana Zepeda-Orozco, Loren E Wold, Daniel Gallego-Perez, Natalia Higuita-Castro
In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness Clarissa Wormsbaecher, Craig Burd, Andrea R Hindman, Alex Avendano, Marcos Cortes-Medina, Caitlin E Jones, Andrew Bushman, Lotanna Onua, Claire E Kovalchin, Alina R Murphy, Hannah L Helber, Ali Shaprio, Kyle Voytovitch, Xingyan Kuang, Renan Aguilar-Valenzuela, Jennifer L Leight, Jonathan W Song
It takes two to Tango: Two gates orchestrate the opening of human TRPM2 Anthony Rish, Tianmin Fu, Zhangfei Shen
Kinesin's front head is gated by the backward orientation of its neck linker Vedud Purde (OSBP alumni), Merve Yusra Dogan, Sinan Can, Frank B Cleary, Ahmet Yildiz
Manganese-dependent microRNA trimming by 3'→5' exonucleases generates 14-nucleotide or shorter tiny RNAs. Cameron Divoky, Kotaro Nakanishi, Sim G, Kehling AC, Park MS, Secor J, Zhang H, Malhotra N, Bhagdikar D, Abd El-Wahab EW
Molecular Origin of Ultrafast Water-Protein Coupled Interactions Dongping Zhong, Dihao Wang (OSBP alumni), Yangzhong Qin, Menghui Jia, Jin Yang, Lijuan Wang, Jianhua Xu
Preparation of fully synthetic histone H3 reveals that acetyl-lysine 56 facilitates protein binding within nucleosomes Justin North, Michael Poirier, John C Shimko (OSBP alumni), Aaron N Bruns (OSBP alumni), Jennifer J Ottesen
Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3. Aubree Zimmer, Juan Alfonzo, Dolce LG, Tengo L, Weis F, Rubio MAT, Kowalinski E
5'-End sequencing in Saccharomyces cerevisiae offers new insights into 5'-ends of tRNAHis and snoRNAs Jane Jackman, Samantha Dodbele (OSBP alumni), Blythe Moreland, Spencer M Gardner, Ralf Bundschuh
A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation Daisy Grove, Michael Kearse
A Microfluidic Chip Enables Isolation of Exosomes and Establishment of Their Protein Profiles and Associated Signaling Pathways in Ovarian Cancer Miranda Gardner, Michael Freitas, Kalpana Deepa Priya Dorayappan, Colin L Hisey, Roman A Zingarelli, Brentley Q Smith, Michelle D S Lightfoot, Rajan Gogna, Meghan M Flannery, John Hays, Derek J Hansford, Lianbo Yu, David E Cohn, Karuppaiyah Selvendiran
A mutation in the THG1L gene in a family with cerebellar ataxia and developmental delay Jane Jackman, Ashanti Matlock (OSBP alumni), Simon Edvardson, Yael Elbaz-Alon, Chaim Jalas, Krishna Patel, Katherine Labbe, Avraham Shaag, Orly Elpeleg
A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin David Wood, Kevin McGarry (OSBP Alumni), Remy F Lalisse, Robert A Moyer, Kristyn M Johnson, Alexi M Tallan, Tyson P Winters, Joeseph E Taris, Craig A McElroy, Erin E Lemmon, Hannah S Shafaat, Yamin Fan, Aniliese Deal, Sean C Marguet, Jill A Harvilchuck, Christopher M Hadad
A photoactive semisynthetic metalloenzyme exhibits complete selectivity for CO2 reduction in water Camille R Schneider (OSBP Alumni), Anastasia C Manesis (OSBP alumni), Michael J Stevenson, Hannah S Shafaat
A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites. Md Siddik Alom, Jahirul Islam M, Nawal Islam N, Kabir M, Halim MA
A Temporal Order in 5'- and 3'- Processing of Eukaryotic tRNAHis Jane Jackman, Tracy M Roach (OSBP alumni), Marie-Theres Pohler, Heike Betat, Mario Morl
A Wide-Field Imaging Approach for Simultaneous Super-Resolution Surface-Enhanced Raman Scattering Bioimaging and Spectroscopy. Brian Scarpitti, Zachary Schultz, Shoup DN
Accessibility of the histone H3 tail in the nucleosome for binding of paired readers Nathaniel Burge, Michael Poirier, Jovylyn Gatchalian, Xiaodong Wang, Jinzen Ikebe, Khan L Cox, Adam H Tencer, Yi Zhang, Luo Di, Matthew D Gibson, Catherine A Musselman, Hidetoshi Kono, Jeffrey J Hayes, Tatiana G Kutateladze
Accounting for Neighboring Residue Hydrophobicity in Diethylpyrocarbonate Labeling Mass Spectrometry Improves Rosetta Protein Structure Prediction. Sarah Biehn, Steffen Lindert, Danielle M Picarello, Xiao Pan, Richard W Vachet
Active site characterization and activity of the human aspartyl (asparaginyl) β-hydroxylase Jenna Greve, James Cowan, Andrew M Pinkham, Zachariah Thompson
Activity and Synergy of Cu-ATCUN Antimicrobial Peptides. Jenna Greve, James Cowan
Adipose Tissue Myeloid-Lineage Neuroimmune Cells Express Genes Important for Neural Plasticity and Regulate Adipose Innervation Miranda Gardner, Magdalena Blaszkiewicz, Gilian Gunsch, Jake W Willows, Jesse A Sepeda, Andrew R Sas, Kristy Townsend
Alternative Protein Topology-Mediated Evolution of a Catalytic Ribonucleoprotein Hong Duc Chau Phan, Venkat Gopalan, Lien B Lai, Walter J Zahurancik (OSBP alumni)
An elastic element in the protocadherin-15 tip link of the inner ear Brandon Neel, Marcos Sotomayor, Raul Araya-Secchi
An Hspa8 variant is a shocking modifier of spinal muscular atrophy in mice. Anton Blatnik, Arthur Burghes
An internal electron reservoir enhances catalytic CO2 reduction by a semisynthetic enzyme Camille R Schneider (OSBP alumni), Hannah S Shafaat
Analyzing protein posttranslational modifications using enzyme-catalyzed expressed protein ligation. Niyi Adelakun, Nam Chu, Jordan Parrish
Antioxidant assessment of agricultural produce using fluorescence techniques: a review Md Siddik Alom, Alin Khaliduzzaman, Ken Abama Omwange, Dimas Firmanda Al Riza, Keiji Konagaya, Mohammed Kamruzzaman, Tiaqi Gao, Yoshito Saito, Naoshi Kondo
Argonaute-based programmable RNase as a tool for cleavage of highly-structured RNA Jonathan Kitzrow, Karin Musier-Forsyth, Kotaro Nakanishi, Daniel M Dayeh (OSBP alumni), William A Cantara
ATP-dependent nucleosome unwrapping catalyzed by human RAD51 Justin North, Michael Poirier, Aarons N Burns (OSBP alumni), Ravindra Amunugama, Marcelina Klajner, Richard Fishel
Autoantibodies targeting TRIM72 compromise membrane repair and contribute to inflammatory myopathy Noah Weisleder, Thomas A Kwiatkowski (OSBP alumni), Kevin E McElhanon, Nicholas Young, Jeffrey Hampton, Brian J Paleo, Eric X Beck, Ana Capati, Kyle Jablonski, Travis Gurney, Miguel A Lopez Perez, Rohit Aggarwal, Chester V Oddis, Wael N Jarjour
Base editing rescue of spinal muscular atrophy in cells and in mice Kaitlyn Kray, Anton Blatnik, Arthur Burghes, Mandana Arbab, Zaneta Matuszek, Ailing Du, Gregory A Newby, Aditya Raguram, Michelle F Richter, Kevin T Zhao, Jonathan M Levy, Max W Shen, W David Arnold, Dan Wang, Jun Xie, Guangping Gao, Daivd R Liu
Characterization of a Salmonella Transcription Factor-DNA Complex and Identification of the Inducer by Native Mass Spectrometry. Blake Szkoda, Vicki Wysocki, Venkat Gopalan, Di Capua A, Shaffer J, Behrman EJ
Chemical and biological tools for the preparation of modified histone proteins Miranda Gardner, Cecil J Howard (OSBP alumni), Ruixuan R Yu (OSBP alumni), John Shimko (OSBP alumni), Jennifer J Ottesen
Co-culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques Ariana Shannon, Amanda Hummon, Claire E Boos
Collective mechanical responses of cadherin-based adhesive junctions as predicted by simulations. Brandon Neel, Marcos Sotomayor, Collin R Nisler, Sanket Walujkar, Raul Araya-Secchi
COLMAR Lipids Web Server and Ultrahigh-Resolution Methods for Two-Dimensional Nuclear Magnetic Resonance- and Mass Spectrometry-Based Lipidomics Abigail Leggett, Rafael Brüschweiler, Cheng Wang, Istavan Timari, Bo Zhang, Da-Wei Li, Amal O Amer, Lei Bruschweiler-Li, Rachel E Kopec
COLMARq: A Web Server for 2D NMR Peak Picking and Quantitative Comparative Analysis of Cohorts of Metabolomics Samples. Abigail Leggett, Rafael Brüschweiler, Da-Wei Li, Lei Bruschweiler-Li
Comparative Analysis of anti-Shine- Dalgarno Function in Flavobacterium johnsoniae and Escherichia coli Zakkary McNutt, Kurt Fredrick, Mai D Gandhi, Elan A Shatoff, Bappaditya Roy, Aishwarya Devaraj, Ralf Bundschuh
Comparison of 4-Mercaptobenzoic Acid Surface-Enhanced Raman Spectroscopy-Based Methods for pH Determination in Cells Brian Scarpitti, Zachary Schultz, Amy M Morrison, Marina Buyanova
Complete sequencing of the SMN2 gene in SMA patients detects SMN gene deletion junctions and variants in SMN2 that modify the SMA phenotype Arthur Burghes, Corey Ruhno (OSBP alumni), Vicki L McGovern, Matthew R Avenarius, Pamela J Snyder, Thomas W Prior, Flavia C Nery, Abdurrahman Muhtaseb, Jennifer S Roggenbuck, John T Kissel, Valerie A Sansone, Jennifer J Siranosian, Alec J Johnstone, Pann H Nwe, Ren Z Zhang, Kathryn J Swoboda
Computational Studies of Cardiac and Skeletal Troponin Steffen Lindert, Jacob D Bowman (OSBP alumni)
Conditional deletion of SMN in cell culture identifies functional SMN alleles Anton Blatnik, Arthur Burghes, Vicki L McGovern, Thanh Le, Chitra C Iyer, Brian Kaspar
Conferring resistance to geminiviruses with the CRISPR-Cas prokaryotic immune system David Bisaro, Aaron N Burns (OSBP alumni), Nicholas J Baltes, Aaron W Hummel, Eva Konecna, Radim Cegan, Daniel F Voytas
Conformational and chemical selection by a trans-acting editing domain Kotaro Nakanishi, Mark Foster, Karin Musier-Forsyth, Eric M Danhart (OSBP alumni), Alexandra B Kuzmishin (OSBP alumni), Marina Bakhtina, William A Cantara, Xiao Ma, Brianne L Sanford, Oscar Vargas-Rodriguez, Marija Kosutic, Yuki Goto, Hiroaki Suga, Ronald Micura
Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis of the 30S subunit of the 70S ribosome Kurt Fredrick, Menglin Chen (OSBP alumni), Rohan Balakrishnan (OSBP alumni), Michelle R Gibbs, Kyung-Mee Moon, Leonard J Foster
Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases Noah Weisleder, Thomas A Kwiatkowski (OSBP alumni), Liubov V Gushchina, Sayak Bhattacharya
Correction to 'Argonaute-based programmable RNase as a tool for cleavage of highly-structured RNA' Jonathan Kitzrow, Karin Musier-Forsyth, Kotaro Nakanishi, Daniel M Dayeh (OSBP alumni), William A Cantara
CRISPR-Cas has a new juggling act: interplay between nuclease and protease. Anthony Rish, Tianmin Fu
Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism Michelle Gray, Marcos Sotomayor
Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with Escherichia coli single stranded DNA binding protein Brian Caldwell, Jordan Hempfling, Dehua Pei, Charles Bell, Ekaterina Zakharova, Gabriel T Filsinger, Timothy M Wannier, Lee Chun-Der, George M Church
Cytoplasmic mRNA recapping has limited impact on proteome complexity Vicki Wysocki, Bernice Agana (OSBP alumni), Dan Shoenberg
Detection of single peptide with only one amino acid modification via electronic fingerprinting using reengineered durable channel of Phi29 DNA packaging motor Miranda Gardner, Julian Aldana Aroca, Michael Freitas, Long Zhang, Lakmal Jayasinghe, Michael Jordan, Nicolas Burns, Peixuan Guo
Detection of single peptide with only one amino acid modification via electronic fingerprinting using reengineered durable channel of Phi29 DNA packaging motor Miranda Gardner, Julian Aldana Aroca, Michael Freitas, Long Zhang, Lakmal Jayasinghe, Michael Jordan, Nicholas Burns, Peixuan Guo
Determinants of target prioritization and regulatory hierarchy for the bacterial small RNA SgrS Tina Henkin, Jane K Frandsen (OSBP alumni), Maksym Bobrovskyy, Muhammad S Azam, Jichuan Zhang, Anustup Poddar, Xiangqian Ma, Taekjip Ha, Carin K Vanderpool
Determination of lentiviral titer by surface enhanced Raman scattering. Brian Scarpitti, Zachary Schultz, Morder CJ, Balss KM
Determination of Protein Surface Hydration by Systematic Charge Mutations Dongping Zhong, Dihao Wang (OSBP alumni), Menghui Jia, Jin Yang, Yangzhong Qin, Haifeng Pan, Lijuan Wang, Jianhua Xu
Differential metabolism between biofilm and suspended Pseudomonas aeruginosa cultures in bovine synovial fluid by 2D NMR-based metabolomics. Abigail Leggett, Rafael Brüschweiler, Da-Wei Li, Lei Bruschweiler-Li, Anne Sullivan, Paul Stoodley
Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B Jane Jackman, Nathan Howell (OSBP alumni), Manasses Jora, Benjamin F Jepson, Patrick A Limbach
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. Claire Hoffman, Vicki Wysocki, Jeff Kuret, Jimenez-Harrison D, Huseby CJ, Sher S, Snyder D, Seal B, Yuan C, Fu H, Giorgini F
Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice Kaitlyn Kray, Arthur Burghes, Vicki McGovern, Deepti Chugh, W David Arnold
Early Inflammation in Muscular Dystrophy Differs between Limb and Respiratory Muscles and Increases with Dystrophic Severity Zachary Howard, Anton Blatnik, Arthur Burghes, Jill Rafael-Fortney, Jeovanna Lowe, Deztani Roberts, Shyam S Bansal
EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions Allison M Webb Chasser (OSBP alumni), Ryan W Johnson, Helen M Chamberlin
Elastic versus brittle mechanical responses predicted for dimeric cadherin complexes. Brandon Neel, Marcos Sotomayor, Collin R Nisler, Sanket Walujkar
Elucidating the Molecular Mechanism of Ultrafast Pfr-State Photoisomerization in Bathy Bacteriophytochrome PaBphP Dongping Zhong, Dihao Wang (OSBP alumni), Yangzhong Qin, Sheng Zhang, Lijuan Wang, Xiaojing Yang
Elucidation of structure-function relationships in Methanocaldococcus jannaschii RNase P, a multi-subunit catalytic ribonucleoprotein. Hong Duc Chau Phan, Mark Foster, Vicki Wysocki, Venkat Gopalan, Norris AS, Du C, Stachowski K, Khairunisa BH, Sidharthan V, Mukhopadhyay B
Enhanced Synergism and Mechanism of Action Studies of Synthetic Antimicrobial Metallopeptides Jenna Greve, James Cowan, Zachariah Thonpson
Enhancing membrane repair increases regeneration in a sciatic injury model Noah Weisleder, Thomas A Kwiatkowski (OSBP alumni), Brian J Paleo, Kathryn M Madalena, Rohan Mital, Kevin E McElhanon, Aubrey L Rose, Jessica K Lerch
Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones Miranda Gardner, Michael Freitas, Benjamin Stanton, Mark Parthun, Liudmila V Popova, Pravakaran Nagarajan, Callie M Lovejoy, Benjamin D Sunkel (OSBP alumni), Meng Wang
Epitranscriptomics in the Heart: a Focus on m6A Christopher Gilbert, Federica Accornero, Jacob Z Longenecker, Volha A Golubeva, Colton R Martens
ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth Christopher Gilbert, Federica Accornero, Jacob Z Longenecker
Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts Miranda Gardner, Michael Freitas, Anuradha Kalyanasundaram, Ning Li, Esthela J Artiga, Brian J Hansen, Amy Webb, Macieh Pietrzak, Bryan A Whitson, Nahush A Mokadam, Paul M L Janssen, Peter Mohler, Vadim V Fedorov
Functional Analysis of BipA in E. coli Reveals the Natural Plasticity of 50S Subunit Assembly Kurt Fredrick, Menglin Chen (OSBP alumni), Michelle R Gibbs, Kyung-Mee Moon, Benjamin R Warner, Ralf Bundschuh, Leonard J Foster
Generation of Proteins with Free N-Terminal Cysteine by Aminopeptidases. Jordan Hempfling, Amanda Hummon, Dehua Pei, Sekera ER, Sarkar A
Genomic and transcriptomic profiling of phoenix colonies. Aubree Zimmer, Juan Alfonzo, Sindeldecker D, Dunn M, Anderson M, Stoodley P
Global analysis of protein synthesis in Flavobacterium johnsoniae reveals the use of Kozak-like sequences in diverse bacteria Zakkary McNutt, Kurt Fredrick, William D Baez, Bappaditya Roy, Elan A Shatoff, Shicheng Chen, Ralf Bundschuh
H1.0 C Terminal Domain Is Integral for Altering Transcription Factor Binding within Nucleosomes. Nathaniel Burge, Michael Poirier, Jenna Thuma, Ziyong Z Hong, Kevin B Jamison, Jennifer J Ottesen
Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent Michelle Gray, Marcos Sotomayor, Zachary R Johnson, Debadrita Modak, Elakkiya Tamilselvan, Matthew J Tyska
Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure Justin North, Michael Poirier, Jonathan W Picking (OSBP alumni), Cecil J Howard (OSBP alumni), Marek Simon, Michelle B Ferdinand, Matthew A Shoffner, Alex M Mooney, John van Noort, Jennifer J Ottesen
HIV-1 Gag protein with or without p6 specifically dimerizes on the viral RNA packaging signal Jonathan Kitzrow, Vicki Wysocki, Karin Musier-Forsyth, Samantha Sarni (OSBP alumni), Erik D Olson (OSBP alumni), Banhi Biswas, Shuohui Liu, Alan Rein
HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio Chathuri Pathirage, Karin Musier-Forsyth, Shuohui Liu, Pratibha C Koneru, Wen Li, Alan N Engelman, Mamuka Kvaratskhelia
HIV-1 Nucleocapsid Protein Binds Double-Stranded DNA in Multiple Modes to Regulate Compaction and Capsid Uncoating Jonathan Kitzrow, Karin Musier-Forsyth, Helena Gien, Michael Morse, Micah J McCauley, Robert J Gorelick, Ioulia Rouzina, Mark C Williams
HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA. Nathaniel Burge, Michael Poirier, Nicklas Sapp, Khan Cox, Prem Prakash, Muthukumar Balasubramaniam, Santosh Thapa, Devin Christensen, Min Li, Jared Lindeberger, Mamuka Kvaratskhelia, Jui Pandhare, Robert Craigie, Chandravanu Dash
How to Build a Metalloenzyme: Lessons from a Protein-Based Model of Acetyl Coenzyme A Synthase Hannah Shafaat, Alina Yerbulekova, Anastasia Manesis (OSBP alumni)
Human Argonaute3 has slicer activity Hong Duc Chau Phan, Vicki Wysocki, Kotaro Nakanishi, Samantha H Hinckley (OSBP alumni), Mi Seul Park, Florian Busch, James A Brackbill
Human aspartyl (asparaginyl) hydroxylase. A multifaceted enzyme with broad intra- and extra-cellular activity Jenna Greve, James Cowan, Andrew M Pinkham
Identification of a Trm732 Motif Required for 2'-O-methylation of the tRNA Anticodon Loop by Trm7. Daisy Grove, Funk HM, Sizemore HE, Wehrle K, Miller CLW, Fraley ME, Mullins AK, Guy AR, Phizicky EM, Guy MP
Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay. Jamison Law, Venkat Gopalan, Anice Sabag-Daigle, Erin F Boulanger, Pankajavalli Thirugnanasambantham, Alex J Bogard, Edward J Behrman, Brian M M Ahmer
Identification of Unknown Metabolomics Mixture Compounds by Combining NMR, MS, and Cheminformatics Abigail Leggett, Rafael Brüschweiler, Cheng Wang, Da-Wei Li, Arpad Somogyi, Lei Bruschweiler-Li
Imaging temozolomide-induced changes in the myeloid glioma microenvironment Miranda Gardner, Claudia Foray, Silvia Valtorta, Cristina Barca, Alexander Winkeler, Wolfgang Roll, Michael Muther, Stefen Wagner, Sven Hermann, Michael Schafers, Oliver Martin Grauer, Rosa Maria Moresco, Bastian Zinnhardt, Andreas H Jacobs
In Vitro Imaging of Lycopene Delivery to Prostate Cancer Cells. Brian Scarpitti, Zachary Schultz, Chitchumroonchokchai C, Clinton SK
Insights into Catalytic and tRNA Recognition Mechanism of the Dual-Specific tRNA Methyltransferase from Thermococcus kodakarensis Jane Jackman, Samantha Dodbele (OSBP alumni), Aiswarya Krishnamohan
Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts Dmitri Kudryashov, Vedud Purde (OSBP alumni), Elena Kudryashov, David B Heisler (OSBP alumni), Reena Shakya
Intragenic complementation of amino and carboxy terminal SMN missense mutations can rescue Smn null mice Kaitlyn Kray, Arthur Burghes, Vicki L McGovern, W. David Arnold, Sandra I Duque, Chitra C Iyer, Aurelie Massoni-Laporte, Eileen Workman, Aalapi Patel, Daniel J Battle
Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR Jonathan Kitzrow, Karin Musier-Forsyth, Benjamin S Brigham, Joshua-Paolo C Reyes, James B Munro
Isolation of Proteins on Nascent Chromatin and Characterization by Quantitative Mass Spectrometry Miranda Gardner, Michael Freitas, Mark Parthun, Paula A Agudelo Garcia
Ligand Field Inversion as a Mechanism to Gate Bioorganometallic Reactivity: Investigating a Biochemical Model of Acetyl CoA Synthase Using Spectroscopy and Computation Effie Kisgeropoulos (OSBP alumni), Anastasia C Manesis (OSBP Alumni), Hannah S Shafaat
Light-Driven Hydrogen Evolution by Nickel-Substituted Rubredoxin Camille R Schneider (OSBP alumni), Michael J Stevenson, Sean C Marguet, Hannah S Shafaat
Measures of single- versus multiple-round translation argue against a mechanism to ensure coupling of transcription and translation Kurt Fredrick, Menglin Chen (OSBP alumni)
Mechanism of Cardiac Troponin C Calcium Sensitivity Modulation by Small Molecules Illuminated by Umbrella Sampling Simulations Steffen Lindert, Jacob D Bowman (OSBP alumni), William H Coldren
Membrane-specific spin trap, 5-dodecylcarbamoyl-5-N-dodecylacetamide-1-pyroline-N-oxide (diC12PO): theoretical, bioorthogonal fluorescence imaging and EPR studies Claire Hoffman, Jeff Kuret, Colwyn A Headley, Juliana M Freisen, Yongbin Han, Joseph M Macklin, Jay L Zweier, Antal Rockenbauer, Frederick A Villamena
Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model Zachary Howard, Federica Accornero, Jill Rafael-Fortney, Lisa E Dorn, Jeovanna Lowe, Megan D Gertzen, Pierce Ciccone, Neha Rastogi, Guy L Odom, Jeffrey S Chamberlain
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy. Zachary Howard, Federica Accornero, Jill Rafael-Fortney, Chetan K Gomatam, Charles P Rabolli, Jevanna Lowe, Arden B Piepho, Shyam S Bansal
Mineralocorticoid Receptor Signaling Contributes to Normal Muscle Repair After Acute Injury Zachary Howard, Federica Accornero, Jill Rafael-Fortney, J Spencer Hauck, Jeovanna Lowe, Neha Rastogi, Madison G Pico, Sarah A Swager, Jennifer M Pertosino, Celso E Gomez-Sanchez, Elise P Gomez-Sanchez
Mineralocorticoid Receptor Signaling in the Inflammatory Skeletal Muscle Microenvironments of Muscular Dystrophy and Acute Injury. Zachary Howard, Jill Rafael-Fortney, Chetan K Gomatam, Arden B Piepho
Modeling Human Cancer-induced Cachexia Noah Weisleder, Melissa Siebert (OSBP alumni), Erin E Talbert, Maria C Cuitino, Katherine J Ladner, Priyani V Rajasekerea, Reena Shakya, Gustavo W Leone, Michael C Ostrowski, Brian Paleo, Peter Reiser, Amy Webb, Cynthia D Timmers, Daniel S Eiferman, David C Evans, Mary E Dillhoff, Carl R Schmidt, Dennis C Guttridge
Molecular Dynamics and Umbrella Sampling Simulations Elucidate Differences in Troponin C Isoform and Mutant Hydrophobic Patch Exposure Steffen Lindert, Jacob D Bowman (OSBP alumni)
Molecular mechanisms of contractile-ring constriction and membrane trafficking in cytokinesis Jian-Qiu Wu, Kenneth S Gerien (OSBP alumni)
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain Blanche Chen, Michael Poirier, Dustin C Becht , Brianna J Klein, Akinori Kanai, Suk Min Jang, Khan L Cox, Bing-Rui Zhou, Sabrina K Phanor, Yi Zhang, Christopher C Ebmeier, Catherine Lachance , Maxime Galloy, Amelie Fradet-Turcotte, Martha L Bulyk, Yawen Bai, Jacques Côté, Akihiko Yokoyama, Tatiana G Kutateladze
MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation Joseph Krzycki, Jonathan W Picking (OSBP alumni), Edward J Behrman, Liwen Zhang
Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters Hong Duc Chau Phan, Marcos Sotomayor, Kotaro Nakanishi, Daniel M Dayeh (OSBP alumni), Mi Seul Park, Raul Araya-Secchi, James A Brackbill, Audrey C Kehling, Ekram W Abd El-Wahab
Multielectron Chemistry within a Model Nickel Metalloprotein: Mechanistic Implications for Acetyl-CoA Synthase Anastasia C Manesis (OSBP alumni), Camille R Schneider (OSBP alumni), Matthew J O'Connor, Hannah S Shafaat
Multiple Imputation Approaches Applied to the Missing Value Problem in Bottom-Up Proteomics Miranda Gardner, Michael Freitas
Multiple poloxamers increase plasma membrane repair capacity in muscle and nonmuscle cells Noah Weisleder, Thomas A Kwiatkowski (OSBP alumni), Aubrey L Rose, Rachel Jung, Ana Capati, Diana Hallak, Rosalie Yan
Mutational Analysis of Redβ Single Strand Annealing Protein: Roles of the 14 Lysine Residues in DNA Binding and Recombination In Vivo Brian Caldwell, Carter Wheat, Charles Bell, Katerina Zakharova, Shayla Ta
Mutational Analysis of Redβ Single Strand Annealing Protein: Roles of the 14 Lysine Residues in DNA Binding and Recombination In Vivo Brian Caldwell, Carter Wheat, Charles Bell, Katerina Zakharova, Shalya Ta
Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury. Zachary Howard, Jill Rafael-Fortney, Neha Rastogi, Jeovanna Lowe, J Spencer Hauck, Pratham Ingale, Chetan Gomatam, Celso E Gomez-Sanchez, Elise P Gomez-Sanchez, Shyam S Bansal
Nearest-Neighbor Effects Modulate loxP Spacer DNA Chemical Shifts and Guide Oligonucleotide Design for Nuclear Magnetic Resonance Studies. Nicole Wagner, Mark Foster
New tRNA contacts facilitate ligand binding in a Mycobacterium smegmatis T box riboswitch Tina Henkin, Jane K Frandsen (OSBP alumni), Anna V Sherwood, Frank J Grundy
Oligomeric complexes formed by Redβ single strand annealing protein in its different DNA bound states Brian Caldwell, Carter Wheat, Marcos Sotomayor, Vicki Wysocki, Charles Bell, Andrew Norris, Ekaterina Zakharova, Christopher E Smith, Deepanshu Choudhary
Oligomeric complexes formed by Redβ single strand annealing protein in its different DNA bound states Brian Caldwell, Carter Wheat, Marcos Sotomayor, Vicki Wysocki, Charles Bell, Andrew Norris, Ekaterina Zakharova, Christopher E Smith, Deepanshu Choudhary
Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins Dmitri Kudryashov, Vicki Wysocki, Vedud Purde (OSBP alumni), Florian Busch, Elena Kudryashov
Phosphomimetic S207D Lysyl-tRNA Synthetase Binds HIV-1 5'UTR in an Open Conformation and Increases RNA Dynamics. Chathuri Pathirage, Karin Musier-Forsyth, William A Cantara, Joshua Hatterschide, Erik D Olson
Phosphorylation of Arabidopsis eIF4E and eIFiso4E by SnRK1 inhibits translation David Bisaro, Aaron N Burns (OSBP alumni), Sizhun Li, Gireesha Mohannath
Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling Justin North, Michael Poirier, Jonathan W Picking (OSBP alumni), Sarah Javaid, Michelle B Ferdinand, Nilanjana Chatterjee, Matthew Shoffner, Robin J Nakkula, Blaine Bartholomew, Jennifer J Ottesen, Richard Fishel
Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity. Songyu Dong, Sarah Heissler, Dmitri Kudryashov, Zheng W, Pinkerton N, Hansen J, Tikunova SB, Davis JP, Kudryashova E, Egelman EH
Plant-exclusive domain of trans-editing enzyme ProXp-ala confers dimerization and enhanced tRNA binding Jun-Kyu Byun, Karin Musier-Forsyth, John A Vu, Siou-Luan He, Jyan-Chyun Jang
Population Distributions from Native Mass Spectrometry Titrations Reveal Nearest-Neighbor Cooperativity in the Ring-Shaped Oligomeric Protein TRAP Vicki Wysocki, Mark Foster, Melody Holmquist (OSBP alumni), Elihu C Ihms, Paul Gollnick
Protein corona-resistant SERS tags for live cell detection of integrin receptors Brian Scarpitti, Zachary Schultz, Sian Sloan-Dennison, MaKenzie R Bevins, Victoria K Sauve
Protein Structure Prediction with Mass Spectrometry Data. Sarah Biehn, Steffen Lindert
Proteomic analysis of the umbilical cord in fetal growth restriction and preeclampsia. Miranda Gardner, Michael Freitas, Matthew S Conrad, Christine Miguel, Kara M Rood, Marwan Ma'ayeh
Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia Miranda Gardner, Dimitrios Papaioannou, Andreas Petri, Oliver M Dovey, Sara Terreri, Eric Wang, Frances A Collins, Lauren A Woodward, Allison E Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kamchala, Marius Bill, Christopher J Walker, Malith Karunasiri, Krzystof Mrozek, Virginia Camilotto, Nina Zitzer, Jonathan L Cooper, Xiongwei Cai, Yi Zheng, Robert J Lee, Iannis Aifantis, George Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D Bloomfield, Adrienne M Dorrance, Ramiro Garzon
Pulsed Multifrequency Electron Paramagnetic Resonance Spectroscopy Reveals Key Branch Points for One- vs Two-Electron Reactivity in Mn/Fe Proteins Hannah Shafaat, Effie Kisgeropoulos (OSBP alumni), Yunqiao J Gan, Samuel M Greer, Joseph M Hazel
Purification of Lumbricus terrestris Mega-Hemoglobin for Diverse Oxygen Therapeutic Applications Christopher Gilbert, Andre Palmer, Chintan Savla, Carlos Munoz, Richard Hickey, Maria Belicak, Pedro Cabrales
Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid α-aminobutyrate Karin Musier-Forsyth, Alexandra B Kuzmishin (OSBP alumni), Jo Marie Bacusmo, William A Cantara, Yuki Goto, Hiroaki Suga
Quantification of miRNAs Co-Immunoprecipitated with Argonaute Proteins Using SYBR Green-Based qRT-PCR Hong Duc Chau Phan, Kotaro Nakanishi, Junan Li, Ming Poi
Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer's Disease Claire Hoffman, Jeff Kuret, Grace L Cooper (OSBP Alumni), Carol J Huseby, Jean-Christophe Cocuron, Ana P Alonso, Stefani N Thomas, Austin J Yang
Quantification of the Mean and Distribution of Hemoglobin Content in Normal Human Blood Using Cell Tracking Velocimetry Christopher Gilbert, Andre Palmer, Jeffrey Chalmers, James Kim, Jenifer Gomez-Pastora, Mitchell Weigand, Nicole A Walters, Eduardo Reategui, Mark Yazer, Maciej Zborowski
Rational design of cell-permeable cyclic peptides containing a d-Pro-l-Pro motif Jordan Hempfling, Mark Foster, Dehua Pei, Jin Wen, Hui Liao, Kye Stachowski, Ziqing Qian, Chunhua Yuan
Real-Time Visualization and Quantification of Contractile Ring Proteins in Single Living Cells Jian-Qiu Wu, Kenneth S Gerien (OSBP alumni), Reshma Davidson, Yajun Liu
Revealing the origin of multiphasic dynamic behaviors in cyanobacteriochrome Dongping Zhong, Dihao Wang (OSBP alumni), Xiankun Li, Sheng Zhang, Lijuan Wang, Xiaojing Yang
Ribosomes lacking bS21 gain function to regulate protein synthesis in Flavobacterium johnsoniae. Zakkary McNutt, Kurt Fredrick, Roy B, Gemler BT, Shatoff EA, Moon KM, Foster LJ, Bundschuh R
RNA Polymerase's Relationship with the Ribosome: Not So Physical, Most of the Time Kurt Fredrick, Menglin Chen (OSBP alumni)
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome Vicki Wysocki, Jackson B Trotman (OSBP alumni), Bernice A Agana (OSBP alumni), Andrew J Giltmier, Daniel R Schoenberg
Roles of Mso1 and the SM protein Sec1 in efficient vesicle fusion during fission yeast cytokinesis Jian-Qiu Wu, Kenneth Gerien (OSBP alumni), Vedud Purde (OSBP alumni), Sha Zhang, Alexandra C Russell, Yi-Hua Shu
Salmonella-Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut Blake Szkoda, Venkat Gopalan, Vicki Wysocki, Jikang Wu, Anice Sabag-Faigle, Mikayla A Borton, Linnea F M Kop, Brooke L Deatherage Kaiser, Stephen R Lindemann, Ryan S Renslow, Siwei Wei, Carrie D Nicora, Karl K Weitz, Young-Mo Kim, Joshua N Adkins, Thomas O Metz, Prosper Boyaka, Kelly C Wrighton, Brian M M Ahmer
Scribe: Next Generation Library Searching for DDA Experiments Brian Searle, Ariana Shannon, Damien Wilburn
Selective packaging of HIV-1 RNA genome is guided by the stability of 5' untranslated region polyA stem Jonathan Kitzrow, Karin Musier-Forsyth, Olga A Nikolaitchik, Shuohui Liu, Yang Liu, Jonathan M O Rawson, Saurabh Shakya, Zetao Cheng, Vinay K Pathak, Wei-Shau Hu
SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA Anton Blatnik, Arthur Burghes, Vicki McGovern, Chitra C Iyer, W David Arnold, Sara E Gombash, Phillip G Zaworski, Kevin D Foust
Solution structure of the nucleotide hydrolase BlsM: Implication of its substrate specificity Vicki Wysocki, Samantha Sarni (OSBP alumni), Minhee Kang, Kiran Doddapaneni, Zach Heppner, Zhengrong Wu
Spectrally Resolved Surface-Enhanced Raman Scattering Imaging Reveals Plasmon-Mediated Chemical Transformations Brian Scarpitti, Zachary Schultz, Carlos Diego L de Albuquerque, Chelsea M Zoltowski, Deben N Shoup
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma Vicki Wysocki, Michael J Koenig, Bernice A Agana (OSBP Alumni), Jacob M Kaufman, Michael F Sharpnack, Walter Z Wang, Christoph Weigel, Fabio C P Navarro, Joseph M Amann, Nicole Cacciato, Rajeswara Rao Arasada, Mark B Gerstein, Christopher Oakes, David P Carbone
Structural basis of sequestration of the anti-Shine-Dalgarno sequence in the Bacteroidetes ribosome Zakkary McNutt, Kurt Fredrick, Vikash Jha, Bappaditya Roy, Dushyant Jahagirdar, Elan A Shatoff, Bethany L Boleratz, Dean E Watkins, Ralf Bundschuh, Kaustuv Basu, Joaquin Ortega
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception Brandon Neel, Marcos Sotomayor, Deepanshu Choudhary, Yoshie Narui, Lahiru N Wimalasena, Carissa F Klanseck, Pedro De-la-Torre, Conghui Chen, Raul Araya-Secchi, Elakkiya Tamiselvan
Structure and mechanism of the Red recombination system of bacteriophage λ Brian Caldwell, Charles Bell
Structure of a RecT/Redβ family recombinase in complex with a duplex intermediate of DNA annealing Brian Caldwell, Vicki Wysocki, Charles Bell, Andrew S Norris, Caroline F Karbowski, Alyssa M Wiegand
Tackling antimicrobial stewardship through synergy and antimicrobial peptides. Jenna Greve, James Cowan
Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin Miranda Gardner, Michael Freitas, Shimaa H A Soliman, Aaron E Stark, Sean W Harshman, Chelssie C Breece, Foued Amari, Arturo Orlacchio, Min Chen, Anna Tessari, Jennifer A Martin, Rosa Visone, Krista M D La Perle, Dario Palmieri, Vincenzo Coppola
The good, the neutral, and the positive: buffer identity impacts CO2 reduction activity by nickel(ii) cyclam Camille R Schneider (OSBP alumni), Luke C Lewis, Hannah S Shafaat
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia Miranda Gardner, Michael Freitas, Dimitrios Papaioannou, Andres Petri, Oliver M Dovey, Sara Terreri, Eric Wang, Frances A Collins, Lauren A Woodward, Allison E Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kumchala, Marius Bill, Christopher J Walker, Malith Karunasiri, Krysztof Mrozek, Virginia Camilotto, Nina Zitzer, Jonathan L Cooper, Xiongwei Cai, Xiaoqing Rong-Mullins, Jessica Kohlschmidt, Kellie J Archer, Yi Zheng, Robert J Lee, Iannis Aifantis, George Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D Bloomfield, Adrienne M Dorrance, Ramiro Garzon
The many faces of RNA-based RNase P, an RNA-world relic. Hong Duc Chau Phan, Venkat Gopalan, Lai LB, Zahurancik WJ
The Mechanical Microenvironment Regulates Axon Diameters Visualized by Cryo-Electron Tomography Di Ma, Chen Gu, Binbin Deng, Chao Sun, David W McComb
Thioester synthesis by a designed nickel enzyme models prebiotic energy conversion. Alina Yerbulekova, Hannah Shafaat, Manesis AC, Shearer J
Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases Isobel Bowles, Jane Jackman, Sarah E Strassler, Debayan Dey, Graeme L Conn
Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases Isobel Bowles, Jane Jackman, Sarah E Strassler , Debayan Dey, Graeme L Conn
Transient kinetic analysis for studying ionizations in RNA modification enzyme mechanisms Jane Jackman, Aiswarya Krishnamohan, Samantha Dodbele
Translation reinitiation after uORFs does not fully protect mRNAs from nonsense-mediated decay Paul Russell, Arthur Burghes, Michael Kearse, Jacob A Slivka, Elaina P Boyle
Use of tandem affinity-buffer exchange chromatography online with native mass spectrometry for optimizing overexpression and purification of recombinant proteins Stella Lai, Jamison Law, Venkat Gopalan, Vicki Wysocki, Pankajavalli Thirugnanasambantham, Vaishnavi Sidharthan, Andrew S Norris
Utilization of Hydrophobic Microenvironment Sensitivity in Diethylpyrocarbonate Labeling for Protein Structure Prediction. Sarah Biehn, Steffen Lindert, Patanachai Limpikirati, Richard W Vachet
Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling. Sarah Biehn, Steffen Lindert, Khaje NA, Eletsky A, Mobley CK, Rogals MJ, Kim Y, Mishra SK, Doerksen RJ, Prestegard JH, Sharp JS
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family Arthur Burghes, Stephen Kolb, Corey Ruhno (OSBP alumni), Stanley Iyadurai, W David Arnold, John T Kissel, Vicki L McGovern, Pamela J Snyder, Thomas W Prior, Jennifer Roggenbuck
Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice Anton Blatnik, Arthur Burghes, Deepti Chugh, Chitra C Iyer, Prameela Bobbili, Brian K Kaspar, Kathrin Meyer, Brian C Clark, W David Arnold
What Genetics Has Told Us and How It Can Inform Future Experiments for Spinal Muscular Atrophy, a Perspective Anton Blatnik, Arthur Burghes, Vicki L McGovern